Protein Laboratories Rehovot Ltd.
November 2019


High-affinity leptin antagonists

by: Prof. Arieh Gertler

We discovered that replacing residue D23 with a non-negatively charged amino acid leads to dramatically enhanced affinity of leptin for its receptor, D23L substitution being the most effective. The resulting D23L/L39A/D40A/F41A mutant acted as super leptin antagonist.